Which of the following groups is at highest risk for poor outcomes in anaphylaxis?
a) Option C is correct: Elderly patients with concomitant cardiovascular or pulmonary diseases are at higher risk for serious complications and death during anaphylaxis, as their physiological reserve is lower and their ability to tolerate hypotension and hypoxia is weaker | b) Option A is incorrect: Healthy young athletes have excellent cardiopulmonary reserve and tolerate shock better | Option B is incorrect: Young children have good compensatory response although doses need weight adjustment | Option D is incorrect: Women of childbearing age without comorbidities are not a high-risk group | Option E is incorrect: Healthy adolescents have good physiological reserve | c) Immediate consultation when: Any elderly patient with cardiac or pulmonary disease experiences anaphylaxis; consultant expected to require intensive monitoring, dose adjustments, and possibly ICU admission | d) What changes the answer: Presence of severe uncontrolled asthma at any age significantly increases risk even in young adults | e) Consultant Pearl: Patients on beta-blockers or ACE inhibitors are at risk for more severe shock and reduced epinephrine response; glucagon may be necessary | f) Sources: Scott Browns Otorhinolaryngology 8th edition volume 1.pdf pp.50-51; CUMMINGS OTOLARYNGOLOGY–HEAD AND NECK 7th Ed p1.pdf p.40