Aminoglycosides (especially gentamicin and streptomycin) and cisplatin are known for their vestibulotoxicity, leading to vestibular hair cell damage and causing permanent bilateral vestibular function loss; high-dose aspirin can cause vestibular symptoms (vertigo, imbalance) but these are usually reversible after drug discontinuation; vestibulotoxicity requires careful monitoring when using these drugs, especially in patients with risk factors (renal insufficiency, high cumulative doses, concurrent use of other ototoxic drugs) | Option D is incomplete because it excludes aspirin, which can also cause vestibulotoxicity | Neuro-otology consultation is indicated when vestibular symptoms (vertigo, imbalance, oscillopsia) appear during treatment with these drugs, to perform vestibular function tests (vHIT, VEMP) | Presence of renal insufficiency significantly increases toxicity risk and requires dose adjustment and drug level monitoring | Prevention includes using lowest effective dose, monitoring renal function, and avoiding concurrent use of other ototoxic drugs | Scott Browns Otorhinolaryngology 8th edition volume 2 — p. 819