A 50-year-old man with allergic rhinitis was prescribed intranasal mometasone spray. After two weeks, he has not experienced significant improvement. What is the most common reason for initial non-response to this class of medications?
a) Intranasal corticosteroids are highly effective in allergic rhinitis | b) The most common reason for non-response to intranasal corticosteroids is poor adherence or incorrect usage technique (such as not directing the spray properly); also, the drug takes time (several days to two weeks) to reach maximum efficacy | c) Bacterial infection is uncommon as a cause of initial non-response | d) Resistance to intranasal corticosteroids is very rare | e) Standard doses are usually sufficient | c) Refer to ENT specialist if non-response persists after confirming correct usage | d) Presence of nasal polyps or severe septal deviation shifts the answer toward need for anatomical assessment | e) Technique matters as much as the drug; proper patient education on nasal spray technique is critical for treatment success | f) Scott Browns Otorhinolaryngology 8th edition volume 1 — p. 1004; EPOS2020 — p. 442