Angioedema
Last Academic Update: May 2, 2026
Overview
A practical and academic emergency approach to angioedema. Not every swollen face or tongue is “allergy” that will be solved with antihistamines. The first on-call decision is: is the airway threatened right now? The second decision is: is this histamine-mediated angioedema that follows the anaphylaxis pathway, or bradykinin-mediated angioedema that does not reliably respond to epinephrine, steroids, or antihistamines? .
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